Ankusham is a story of an honest cop who goes to extremes to ensure that he gets to roots of crime. In a murder mystery he asks a witness, a woman, to stay with him. Gradually, they both fall in love. However, the criminal whom they both had sent to jail vows revenge. The personal revenge saga becomes a political issue, with even Chief Minister of a state happening to involve with the family of the honest cop. How the hero handles situations at home and in society becomes one of the most respected Telugu movies.